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Home»Sports»2025 CFP Odds: Strains, Spreads for Every Opening Sport
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2025 CFP Odds: Strains, Spreads for Every Opening Sport

dramabreakBy dramabreakDecember 20, 2025No Comments3 Mins Read
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2025 CFP Odds: Strains, Spreads for Every Opening Sport
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Now that the College Football Playoff bracket is set, bettors are looking ahead to the odds for the first round of games.

Notably, Ole Miss and Oregon open as massive, double-digit favorites over Tulane and James Madison, respectively. 

Let’s look at the odds at DraftKings Sportsbook as of Dec. 20.

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FRIDAY, DEC. 19

No. 9 Alabama 34, No. 8 Oklahoma 24

Spread: Alabama -1.5 (Alabama covers)
O/U: 40.5 (Over hits)

What to know: These two teams faced off during the regular season, back on Nov. 15. In that game, the Sooners traveled to Alabama and beat the Tide, 23-21. However, the Tide returned the favor on Friday, beating Oklahoma in Norman to move to the CFP quarterfinals. It wasn’t easy though. OU led 17-0 early in the second quarter, before Bama allowed just seven points the rest of the game, scoring 34 of its own. Ty Simpson completed 18 of 29 passes for 232 yards and two scores. Next up for Alabama is No. 1 Indiana on New Year’s Day.

SATURDAY, DEC. 20

No. 10 Miami @ No. 7 Texas A&M (noon ET, ABC)

Spread: Texas A&M -3.5
Moneyline: Texas A&M -162, Miami +136
O/U: 48.5 

What to know: These teams did not face off in the regular season, but they do have some common opponents. Miami beat Notre Dame in Week 1 27-24, and the Aggies defeated the Irish 41-40 in Week 3. Those two losses eventually ended up dooming Notre Dame’s Playoff chances. These squads’ other common opponent is Florida, which the Aggies beat 34-17, and the Hurricanes beat 26-7. 

No. 11 Tulane @ No. 6 Ole Miss (3:30 p.m. ET, TNT)

Spread: Ole Miss -17.5
Moneyline: Ole Miss -950, Tulane +625
O/U: 57.5

What to know: Quite the spread on this one, huh? Well, Tulane has faced two ranked opponents so far this season. Back on Sept. 20, it lost at then-No. 13 Ole Miss 45-10, and then, in the American title game this past weekend, it beat No. 24 North Texas 34-21. That’s it. Now, the Green Wave get Ole Miss again. In that game, the Rebels led 45-3 before Tulane scored its first TD of the night with 3:42 left in the game. 

No. 12 James Madison @ No. 5 Oregon (7:30 p.m. ET, TNT)

Spread: Oregon -20.5
Moneyline: Oregon -1800, James Madison +1000
O/U: 46.5

What to know: Remember when we were talking about large spreads? Unlike Tulane, James Madison faced zero ranked teams this season. Its one regular-season loss came at Louisville (28-14) back on Sept. 5. The Dukes would go on to win 11 straight after that, including a 31-14 win over Troy in the Sun Belt Championship Game. Now, JMU gets Oregon, a team with one loss on the season — a 10-point setback against the No. 1 seed in the CFP, Indiana, back on Oct. 11 (20-10).

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